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HIV-1 Infection and Nervous System Abnormalities Among a Cohort of Intravenous Drug Users Neurol 41:1905-1910, Royal III,W.,et al, 1991 See this aricle in Pubmed Article Abstract A group of 109 HIV seropositive and 51 seronegative intravenous drug users was evaluated for the presence of HIV-1-related neurologic disease using clinical,neurologic,neuropsychological,and electrophysiologic evaluations. About 80%of HIV seropositive subjects had less than two constitutional symptoms.CD4 cell counts were less than 500 mm3 among 56 of seropositive participants;three individuals were receiving zidovudine.Neurologic abnormalities were found frequently among the cohort,independently of HIV- 1 serostatus;electrophysiologic abnormalities were uncommon.Participants from both serologic groups scored significantly lower on neuropsychological tests as compared with norms established for a cohort of homosexual men,and there was no clear association between HIV-1 serostatus and performance on these tests.This study suggests that HIV infection was not the dominant cause of neurologic abnormalities among the study cohort.

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